Nucleoside-modified AdoMet analogues for differential methyltransferase targeting

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Resistance Mechanisms for Nucleoside Analogues

The aim of the thesis was to elucidate the mechanisms underlying resistance to nucleoside analogues used in the treatment of leukemias, with focus on cellular metabolism and induction of apoptosis. Cladribine (CdA), Clofarabine (CAFdA), Fludarabine (Fara-A) and Nelarabine (Ara-G) are nucleoside analogues with activity against various types of leukemias. CAFdA is a relatively new nucleoside anal...

Inducible and constitutive nucleoside-binding sites in Escherichia coli: differential inhibition by nucleoside analogues.

Constitutive and inducible nucleoside-binding sites on the surface of the cells of E. coli B have different patterns of inhibition by nucleoside analogues. 1(beta-D-Ribofuranosyl)-4-aminopyrimidine-6-one and isoguanosine preferentially inhibit the inducible binding sites while showdomycin and N(4)-dimethylcytidine interfere more strongly with the constitutive function.

Nucleoside analogues and mitochondrial toxicity.

An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuro...

Nucleoside Analogues and Mitochondrial Toxicity

Infectious Diseases Unit, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. Received for publication: January 17, 2006. Reprint request: Ubonvan Jongwutiwes, M.D., Infectious Diseases Unit, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. E-mail: [email protected]